A convenient synthetic approach to alpha-amino-beta-lactam synthesis promoted by phenyl dichlorophosphate reagent |
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Authors: | Jesus M. Aizpurua Inlaki Ganboa Fernando P. Cossío Alberto Gonzalez Ana Arrieta Claudio Palomo |
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Affiliation: | Kimika Organikako Departamendua, Kimika Fakultatea, Euskal Herriko Unibertsitatea, Altza, Donostia, Spain. |
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Abstract: | The ready and economical phenyl dichlorophosphate, in contrast to many reagents developed for activating carboxyl groups for the beta-lactam synthesis, is shown to be very efficient for the synthesis of alpha-vinylamino-beta-lactams from Dane salts and Schiff bases. Some observations toward the scope of the method are also briefly described. The interaction of acetic acids with ethanolimines afforded beta-lactams and/or oxazolidines according to the synthetic methodology used. |
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