Structural and conformational studies on euphornin and related diterpenes |
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Authors: | Yoshikazu Shizuri Seiji Kosemura Jiro Ohtsuka Yukimasa Terada Shosuke Yamamura Shigeru Ohba Masatoki Ito Yoshihiko Saito |
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Institution: | 1. Faculty of Pharmacy, Meijo University, Tempaku-ku, Nagoya, Japan |
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Abstract: | In addition to euphornin, three new toxic substances (euphornins A, B and C) have been isolated from the plant L., and their absolute stereostructures also been elucidated on the basis of their spectral data and some chemical evidence together with an X-ray crystallographic analysis of the p-bromobenzoate derived from euphornin. Furthermore, their conformations have also been discussed. |
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