Stereoselective synthesis of (25<math><mtext>R</mtext></math>)-25,26-dihydroxy-23-oxovitamin D3 and its enzymatic conversion to (25<math><mtext>R</mtext></math>)-1α,25,26-trihydroxy-23-oxovitamin D3, a putative metabolite of vitamin D3期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Stereoselective synthesis of (25 $R$ )-25,26-dihydroxy-23-oxovitamin D₃ and its enzymatic conversion to (25 $R$ )-1α,25,26-trihydroxy-23-oxovitamin D₃, a putative metabolite of vitamin D₃

Authors:	Sachiko Yamada Keiko Nakayama Hiroaki Takayama Toshimasa Shinki Tatsuo Suda

Affiliation:	Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa 199-01, Japan;The Department of Biochemistry, School of Dentistry, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142, Japan

Abstract:	(25 $R$ )-25,26-Dihydroxy-23-oxovitamin D₃ was synthesized efficiently and stereoselectively, and it was converted enzymatically to (25 $R$ )-1α,25,26-trihydroxy-23-oxovitamin D₃, a putative metabolite of 1α,25-dihydroxyvitamin D₃. The spectral and chemical properties of (25 $R$ )-25,26-dihydroxy-23-oxovitamin D₃ and its 1α,hydroxylated derivative disagree with those reported for the isolated metabolite.

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