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Regio-specific total synthesis of (±)-2-hydroxyaklavinone |
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| Authors: | Hiroshi Tanaka Takeo Yoshioka Yasutaka Shimauchi Akihiro Yoshimoto Tomoyuki Ishikura Hiroshi Naganawa Tomio Takeuchi Hamao Umezawa |
| Institution: | Sanraku-Ocean Co., Ltd., Central Research Laboratories, Johnan, Fujisawa 251, Japan;Institute of Microbial Chemistry, Kamiosaki, Shinagawa, Tokyo 141, Japan |
| Abstract: | The tricyclic quinone 8 was successfully synthesized from naphthazalin, and the total synthesis of (±)-2-hydroxyaklavinone via 8 was accomplished in an overall yield of about 18% through the regio-controlled route. |
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