Synthesis and nucleophilic substitutions of 3-alkyl-5-chloroisoxazoles |
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| Authors: | R.V. Stevens K.F. Albizati |
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| Affiliation: | Department of Chemistry and Biochemistry University of California at Los Angeles Los Angeles, CA 90024 U.S.A. |
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| Abstract: | A 3-alkyl-5-chloroisoxazole synthesis is described based on the cycloaddition of nitrile oxides to 1,1-dichloroethylene, an inexpensive dipolarophile. Substitution of the chloride in these adducts by various nucleophiles is also described. |
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