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Synthesis and nucleophilic substitutions of 3-alkyl-5-chloroisoxazoles
Authors:RV Stevens  KF Albizati
Institution:Department of Chemistry and Biochemistry University of California at Los Angeles Los Angeles, CA 90024 U.S.A.
Abstract:A 3-alkyl-5-chloroisoxazole synthesis is described based on the cycloaddition of nitrile oxides to 1,1-dichloroethylene, an inexpensive dipolarophile. Substitution of the chloride in these adducts by various nucleophiles is also described.
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