A convenient synthesis of geiparvarin |
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| Authors: | Takashi Sakai Hiroshi Ito Akitoshi Yamawaki Akira Takeda |
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| Affiliation: | Department of Synthetic Chemistry, School of Engineering, Okayama University, Tsushima, Okayama 700, Japan |
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| Abstract: | Acylation of 3-methyl-2,3-bis(trimethylsiloxy)-l-butene (PhLi) with (E)-2-methyl-2-butenoyl chloride gives the corresponding 3(2H)-furanone derivative, which can be readily converted to the naturally occurring antitumor agent Geiparvarin by two steps. |
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