Silafunctional compounds in organic synthesis. 27. (Isopropoxydimethylsilyl)methyl grignard reagent: A new nucleophilic hydroxymethylating agent for aldehydes and ketones |
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| Authors: | Kohei Tamao Neyoshi Ishida |
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| Affiliation: | Department of Synthetic Chemistry, Kyoto University, Yoshida, Kyoto 606, Japan |
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| Abstract: | Nucleophilic hydroxymethylation of aldehydes and ketones has been achieved by the reaction with the (isopropoxydimethylsilyl)methyl Grignard reagent and the subsequent oxidative cleavage of the carbon-silicon bond. |
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