Penicillin-cephalosporin conversion X. New synthesis of dithioazetidinones from thiazoline-azetidinones |
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Authors: | Sigeru Torii Hideo Tanaka Takashi Siroi Michio Sasaoka |
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Affiliation: | Department of Industrial Chemistry, School of Engineering, Okayama University, Okayama 700, Japan |
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Abstract: | New ring-opening reaction of thiazoline-azetidinones 1 to dithioazetidinones 2 was achieved with 2-benzothiazolyl disulfide in aqueous acidic media and its potentiality for the preparation of a variety of cephalosporins 3 from various thiazoline-azetidinones 1 is demonstrated. |
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