Synthesis of unnatural amino acids: spiro[4.5]-2-aza-decan-3-carboxylic acid |
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Authors: | V. Teetz H. Gaul |
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Affiliation: | Hoechst Aktiengesellschaft, D-6230 Frankfurt/Main 80 Germany |
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Abstract: | Spiro[4.n]-2-aza-alkan-carboxylic acids represent bulky proline analogues with increased lipophilicity. They are readily available from cyclic nitriles via alkylation with bromoacetaldehyde acetals, reduction to the corresponding amine, cyclisation to the imine and subsequent Strecker synthesis. |
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