Proposed structure of the cyclic peptide dolastatin 3, a powerful cell growth inhibitor,should be revised! |
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Authors: | Yasumasa Hamada Kohfuku Kohda Takayuki Shioiri |
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Institution: | Faculty of Pharmaceutical Sciences, Nagoya City University, Tanabe-dori, Mizuho-ku, Nagoya 467, Japan |
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Abstract: | The cyclic peptide proposed for the structure of the powerful cell growth inhibitory dolastatin 3, its diastereomers, and their isomers on the reverse order have been synthesized by the use of diphenyl phosphorazidate(DPPA) and diethyl phosphorocyanidate(DEPC). Their physicochemical and biological properties have shown that the proposed structure is untenable. |
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