Cycloaddition reactions of 1.3-benzothiazines v synthesis of new tetracyclic ring systems |
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Authors: | Lajos Fodor János Szabó Gábor Bernáth Pál Sohár |
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Institution: | Central Laboratory, County Hospital. H-5701 Gyula, POB 46, Hungary;Inst. Pharm. Chem., Univ. Med. School, H-6701 Szeged, POS 121 Hungary;Spectroscopic Dept., EGYT Pharmacochem. Works, H-1475 Budapest, POB 100, Hungary |
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Abstract: | New tetracyclic derivatives (3a,, 5, 8) similar to protoberberines, but containing a lactam structural element and other hetero atoms besides the bridge-head nitrogen in rings B and C, were prepared by cycloaddition of 6,7-dimethoxy-2H-1,3-benzothiazine (1a) with -substituted aromatic carboxylic acid derivatives (2a,, 4) and from 4- methyl-6,7-dimethoxy-2-1,3-benzothiazine (1b) with 3.5-dinitrobenzoyl chloride. |
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