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A short,three-component total synthesis of 12-hydroxyeicosa-5,8,14(Z), 10(E)-tetraenoic acid (12-HETE) via the corresponding ketone |
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| Authors: | EJ Corey Keith Kyler Natarajan Raju |
| Institution: | Department of Chemistry, Harvard University, Cambridge, Massachusetts 02138 U.S.A. |
| Abstract: | A highly effective synthesis of (±)-12-HETE (1) from the components 2, 3 and 6 is described which employs a new class of cuprate reagents. |
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