Total synthesis of protomycinolide iv |
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| Authors: | Masanori Honda Tsutomu Katsuki Masaru Yamaguchi |
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| Affiliation: | Department of Chemistry, Kyushu University 33, Hakozaki, Higashi-ku, Fukuoka 812, Japan |
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| Abstract: | A 16-membered macrolide antibiotic, protomycinolide IV, was synthesized from two fragments to which the chirality was introduced by asymmetric epoxidation of the appropriately chosen allylic alcohols. A new synthesis of the Prelog-Djerassi lactonic acid from one of the intermediates of the synthesis was also carried out. |
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