An alternative synthesis of the 1-oxacephem skeleton |
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Authors: | Sadao Yamamoto Hikaru Itani Hiroumi Takahashi Teruji Tsuji Wataru Nagata |
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Affiliation: | Shionogi Research Laboratories, Shionogi & Co., Ltd., Fukushima-ku, Osaka 553, Japan |
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Abstract: | 1-Oxacephem skeletons were constructed in a convergent manner starting from building blocks and , which were easily prepared from penicillin and diketene, respectively, followed by intramolecular carbene insertion reaction of the resulting intermediate . |
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