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An alternative synthesis of the 1-oxacephem skeleton
Authors:Sadao Yamamoto  Hikaru Itani  Hiroumi Takahashi  Teruji Tsuji  Wataru Nagata
Institution:Shionogi Research Laboratories, Shionogi & Co., Ltd., Fukushima-ku, Osaka 553, Japan
Abstract:1-Oxacephem skeletons were constructed in a convergent manner starting from building blocks B and C, which were easily prepared from penicillin and diketene, respectively, followed by intramolecular carbene insertion reaction of the resulting intermediate A.
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