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| N-[5-(Е)-1,3,4-噻二唑-2-基]-N'-芳基脲的合成、晶体结构及生物活性 | |
| 引用本文： | 宋新建,王发松,李世荣,胡卫兵,汪焱钢.N-[5-(Е)-1,3,4-噻二唑-2-基]-N'-芳基脲的合成、晶体结构及生物活性[J].有机化学,2011,31(4). |
| 作者姓名： | 宋新建 王发松 李世荣 胡卫兵 汪焱钢 |
| 作者单位： | 1. 湖北民族学院生物资源保护与利用湖北省重点实验室,恩施445000;华中师范大学化学学院,武汉430079 2. 湖北民族学院生物资源保护与利用湖北省重点实验室,恩施,445000 3. 华中师范大学化学学院,武汉,430079 |
| 基金项目： | 湖北省自然科学基金，湖北民族学院科研创新团队资助项目 |
| 摘 要： | 为了寻找高活性的脲类细胞分裂素,通过2-氨基-5-(Е)-苯乙烯基-1,3,4-噻二唑与芳酰基叠氮化物反应,合成了11种新的含1,3,4-噻二唑环芳基脲类衍生物,其中芳酰基叠氮化物直接由芳酸、三氯氧磷与叠氮钠采用"一锅法"制得,再经加热发生Curtius重排转化为异氰酸酯.目标化合物的结构用红外光谱、核磁共振氢谱、质谱和元素分析进行了表征,并用X射线单晶衍射实验测定了化合物3g的结构.初步的生物活性测试表明,部分目标化合物在10 mg/L浓度下表现出良好的细胞分裂素活性,其中3c的活性超过50%. |
| 关 键 词： | 1 3 4-噻二唑 酰基叠氮化物 脲 合成 晶体结构 细胞分裂素 |
Synthesis, Crystal Structure and Biological Activity of N-[5-( E)-Styryl- 1,3,4-th iad iazol-2-yl]-N'-a ryl ureas |
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| Song Xinjian,Wang Fasong,Li Shirong,Hu Weibing,Wang Yangang.Synthesis, Crystal Structure and Biological Activity of N-[5-( E)-Styryl- 1,3,4-th iad iazol-2-yl]-N'-a ryl ureas[J].Chinese Journal of Organic Chemistry,2011,31(4). | |
| Authors: | Song Xinjian Wang Fasong Li Shirong Hu Weibing Wang Yangang |
| Institution: | Song,Xinjian~(*,a,b)Wang,Fasong~a Li,Shirong~a Hu,Weibing~a Wang,Yangang~b (a Key Laboratory of Biological Resources Protection and Utilization of Hubei Province,Hubei University for Nationalities,Enshi 445000) (b College of Chemistry,Central China Normal University,Wuhan 430079) |
| Abstract: | With the aim of searching for highly bioactive urea-type cytokinins,eleven novel arylurea derivatives containing a 1,3,4-thiadiazole group were synthesized by the reaction of 2-amino-5-(E)-styryl- 1,3,4-thiadiazole with aroyl azides,which were efficiently prepared directly from their respective carboxylic acids,phosphorous oxychloride and sodium azide by one-pot procedure,then underwent a Curtius rearrangement upon heating to form the corresponding isocyanates.The structures of these title compounds were ch... |
| Keywords: | 1 3 4-thiadiazole acyl azide urea synthesis crystal structure cytokinin |
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