| 吲哚-2-甲酸和(S)-吲哚啉-2-甲酸的合成和相互转化研究进展 |
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| 引用本文： | 刘金强,钱超,陈新志.吲哚-2-甲酸和(S)-吲哚啉-2-甲酸的合成和相互转化研究进展[J].有机化学,2011,31(5). |
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| 作者姓名： | 刘金强 钱超 陈新志 |
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| 作者单位： | 1. 浙江大学化学工程与生物工程学系,杭州,310027;洛阳师范学院化学化工学院,洛阳,471022
2. 浙江大学化学工程与生物工程学系,杭州,310027 |
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| 基金项目： | 国家自然科学基金，浙江省自然科学基金 |
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| 摘 要： | 吲哚-2-甲酸和(S)-吲哚啉-2-甲酸均是具有生物活性的天然产物和众多降压药的特征结构片段,报道了它们的合成及其相互转化研究进展.吲哚啉-2-甲酸可由吲哚-2-甲酸还原制得,其中(S)-吲哚啉-2-甲酸可由外消旋体拆分或通过不对称合成法制备,其中"手性源法"作为一种新出现的方法具有较好的前景.吲哚-2-甲酸可由Fischer吲哚合成法制备,或通过取代苯胺或苯甲醛制备,也可通过吲哚啉衍生物氧化脱氢制备,其中Fischer合成法仍具有较强的竞争力.
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| 关 键 词： | 吲哚-2-甲酸 吲哚啉-2-甲酸 相互转化 研究进展 |
Syntheses of Indole-2-carboxylic Acid and Indoline-2-carboxylic Acid and Transformation from Each Other |
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| Liu Jinqiang,Qian Chao,Chen Xinzhi.Syntheses of Indole-2-carboxylic Acid and Indoline-2-carboxylic Acid and Transformation from Each Other[J].Chinese Journal of Organic Chemistry,2011,31(5). |
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| Authors: | Liu Jinqiang Qian Chao Chen Xinzhi |
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| Institution: | Liu,Jinqianga,b Qian,Chaoa Chen,Xinzhi*,a(a Department of Chemical and Biological Engineering,Zhejiang University,Hangzhou 310027)(b College of Chemistry and Chemical Engineering,Luoyang Normal University,Luoyang 471022) |
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| Abstract: | Indole-2-carboxylic acid and indoline-2-carboxylic acid are common building block in natural products with bioactivities and anti-hypertension pharmaceuticals.The syntheses and transformation from each other were reviewed.Indoline-2-carboxylic acid can be got from the reduction of indole-2-carboxylic acid and the S enantiomer can be achieved from the resolution of the racemic mixture with chemical reagents or enzymes.The chiral pool synthesis,emerged recently,will play an important role in the future.In-dol... |
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| Keywords: | indole-2-carboxylic acid indoline-2-carboxylic acid transformation progress |
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