| 香豆素席夫碱衍生物的合成及抗肿瘤活性研究 |
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| 引用本文： | 王辉,郑伟华,谢凤妮,宋化灿.香豆素席夫碱衍生物的合成及抗肿瘤活性研究[J].有机化学,2011,31(5). |
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| 作者姓名： | 王辉 郑伟华 谢凤妮 宋化灿 |
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| 作者单位： | 1. 华南师范大学化学与环境学院,广州,510006
2. 中山大学化学与化学工程学院,广州,510275 |
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| 摘 要： | 设计合成了18个未见文献报道的含席夫碱结构的香豆素衍生物,其结构经1H NMR,13C NMR,ESI-MS和元素分析确证.体外对人口腔鳞癌细胞KB及多药耐药株KBv200的初步毒性试验表明,化合物4a,4b,5b,3d和4d具有中等的抗肿瘤活性,并对其构效关系进行了讨论.
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| 关 键 词： | 香豆素衍生物 席夫碱 抗肿瘤活性 KB和KBv200 |
Synthesis and Biological Evaluation of Coumarin Schiff Base Derivatives as Novel Antitumor Inhibitors |
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| Wang Hui,Zheng Weihua,Xie Fengni,Song Huacan.Synthesis and Biological Evaluation of Coumarin Schiff Base Derivatives as Novel Antitumor Inhibitors[J].Chinese Journal of Organic Chemistry,2011,31(5). |
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| Authors: | Wang Hui Zheng Weihua Xie Fengni Song Huacan |
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| Institution: | Wang,Huia Zheng,Weihuaa Xie,Fengnia Song,Huacan*,b(a School of Chemistry and Environment,South China Normal University,Guangzhou 510006)(b School of Chemistry and Chemical Engineering,Sun Yat-sen University,Guangzhou 510275) |
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| Abstract: | A series of coumarin Schiff base analogues were synthesized.Their structures were character-ized by 1H NMR,13C NMR,ESI-MS techniques and elemental analysis.Preliminary bioassays for in vitro antitumour activities against KB and KBv200 cells indicated that compounds 4a,4b,5b,3d and 4d exhib-ited middle potent antitumour activities.The relatives of structure and activity were discussed. |
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| Keywords: | coumarin derivative Schiff base antitumor activity KB and KBv200 |
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