Total synthesis of the formamicin aglycon,formamicinone |
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Authors: | Savall Brad M Blanchard Nicolas Roush William R |
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Institution: | Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA. |
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Abstract: | structure: see text] The total synthesis of formamicinone (2), the aglycone of formamicin (1), has been accomplished via the late-stage Suzuki cross-coupling of fragments 5 and 6, the macrolactonization of seco ester 14, and the Mukaiyama aldol reaction of aldehyde 3 and methyl ketone 4. An efficient and highly stereoselective second generation synthesis of vinyl iodide 6 is also described. |
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