Stereoelectronic interaction and their effects on conformational preference for 2-substituted methylenecyclohexane: an experimental and theoretical investigation |
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Authors: | Anizelli Pedro R Vilcachagua Janaina D Neto Alvaro Cunha Tormena Cláudio F |
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Affiliation: | Department of Organic Chemistry, Chemistry Institute, University of Campinas-UNICAMP-CEP, P. O. Box 6154, 13084-971 Campinas, SP, Brazil. |
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Abstract: | Conformational preferences for 2-substituted methylenecyclohexanes were determined using (3) J H 2 H 3 spin-spin coupling constants, while stereoelectronic interactions were obtained by means of theoretical calculations and NBO analysis. The conformational equilibrium of compounds studied can be represented by their axial and equatorial conformers, the axial conformers being the most stable form in polar and nonpolar solvents. These conformational preferences were attributed to the hyperconjugative interactions between the pi C-C-->sigma* C-Xax. and sigma C-H-->sigma* C-Xax. orbitals, and the repulsive steric interaction observed between sigma C-H-->n Xeq.. |
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