| 3-羟基十四酸的合成 |
| |
| 引用本文： | 刘磊,念保义,徐刚,吴坚平,杨立荣.3-羟基十四酸的合成[J].合成化学,2007,15(5):619-621. |
| |
| 作者姓名： | 刘磊 念保义 徐刚 吴坚平 杨立荣 |
| |
| 作者单位： | 1. 浙江大学,材料与化学工程学院,浙江,杭州,310027;浙江大学,生物工程研究所,浙江,杭州,310027
2. 三明学院,化学与生物工程系,福建,三明,365004 |
| |
| 基金项目： | 国家自然科学基金资助项目(20606030) |
| |
| 摘 要： | 以环氧氯丙烷为起始原料,经5步反应合成了3-羟基十四酸,总收率52.48%。以氯癸烷替代溴癸烷做格氏反应,有效地降低了偶联副产物的生成;从中间产物1-氯-2-羟基十三烷直接上氰基,避免了环化后上氰基时生成氢氰酸的危险。
|
| 关 键 词： | 氯癸烷 格氏反应 环氧氯丙烷 氰化钠 合成 |
| 文章编号： | 1005-1511（2007）05-0619-03 |
| 收稿时间： | 2007-04-23 |
| 修稿时间： | 2007年4月23日 |
Synthesis of 3-Hydroxytetradecanoic Acid |
| |
| LIU Lei,NIAN Bao-yi,XU Gang,WU Jian-ping,YANG Li-rong.Synthesis of 3-Hydroxytetradecanoic Acid[J].Chinese Journal of Synthetic Chemistry,2007,15(5):619-621. |
| |
| Authors: | LIU Lei NIAN Bao-yi XU Gang WU Jian-ping YANG Li-rong |
| |
| Institution: | 1. Institute of Biochemical Engineering;2. College of Material Science and Chemical Engineering, Zhejiang University, Hangzhou 310027, China; 3. Department of Chemical and Biochemical Engineering, Sanming College, Sanming 365004, China |
| |
| Abstract: | 3-Hydroxytetradecanoic acid was synthesized by a five-step reaction from epichlorohydrin in overall yield of 52.48%.The decyl chloride was used instead of 1-bromodecane to produce Grignard reagent to reduce production of the byproduct eicosane;intermidiate 1-chloro-2-hydroxytridecane was used directly to react with sodium cyanide,which could avoid generating virulent hydrocyanic acid. |
| |
| Keywords: | decyl chloride Grignard reaction epichlorohydrin sodium cyanide synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
