Facile discrimination of aldose enantiomers by reversed-phase HPLC |
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| Authors: | Tanaka Takashi Nakashima Tatsuya Ueda Toshihisa Tomii Kenji Kouno Isao |
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| Affiliation: | Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. t-tanaka@nagasaki-u.ac.jp |
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| Abstract: | One-pot reactions of aldoses with L-cysteine methyl ester and o-tolyl isothiocyanate yielded methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbamoyl)-thiazolidine-4(R)-carboxylates. Direct HPLC analysis of the reaction mixture and UV detection at 250 nm discriminated D- and L-enantiomers of aldoses. The reaction was applied to the determination of absolute configuration the sugar residues of an aroma precursor. |
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