Optimization of iodine determination according to Schöniger
Analytical chemistry with 1,3-dibromo-5,5-dimethylhydantoin (DBH)a Part 1, Oxygen flask combustion Part 7 [1, 2] |
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Authors: | Manfred Hilp |
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Institution: | Institut für Pharmazeutische Chemie der Philipps-Universit?t, Marbacher Weg 6, D-35032 Marburg e-mail: Hilp@pharmazie.uni-marburg.de, XX
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Abstract: | The method of iodine determination in organic compounds according to Schöniger 3, 4] was improved by using an alkaline absorption solution of DBH. In contrast to elemental bromine DBH is a stable and easy to handle crystalline compound. For the removal of the excess of DBH 5-sulfosalicylic acid (C7H6O6S × 2H2O 5965-83-3]) 5] is more suitable than formic acid 64-18-6]. Assays for the determination of 2-iodobenzoic acid in the range from 1 to 25 mg iodine are described. 32 organic iodine compounds, mostly x-ray contrast media, could be analyzed with a percentage relative standard deviation of about 0.2%. |
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