Ring closure to beta-turn mimics via copper-catalyzed azide/alkyne cycloadditions |
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Authors: | Angell Yu Burgess Kevin |
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Institution: | Chemistry Department, Texas A & M University, P.O. Box 30012, College Station, Texas 77842, USA. |
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Abstract: | Structure: see text]. Copper-catalyzed azide alkyne cycloadditions of the linear substrates 1 were used to form the cyclic derivatives 2. Computational, NMR, and CD analyses of these compounds indicate that their most favorable conformational states include type I and type II beta-turn conformations. Selectivity for the dimeric products 6 in these cyclization reactions is discussed. |
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