Facile two-step synthesis of crispine A and harmicine by cyclopropylimine rearrangement |
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| Authors: | Sanjay Saha Ch. Venkata Ramana ReddyBalaram Patro |
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| Affiliation: | a GVK Biosciences Private Limited, Medicinal Chemistry Division, 28A, IDA Nacharam, Hyderabad 500076, India
b Department of Chemistry, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad 500085, India |
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| Abstract: | The synthesis of 4 and 8 is reported. These intermediates are obtained by a one-pot tandem cyclization of 1 and 6, respectively, via Bischler Napieralski reaction followed by cyclopropylimine rearrangement. Compounds 4 and 8 were reduced by sodium borohydride in methanol to afford cytotoxic alkaloid (±)-crispine A and antileishmania compound (±)-harmicine. |
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