A facile synthesis of a polyhydroxylated 2-azabicyclo[3.2.1]octane |
| |
Authors: | Reed Damon D Bergmeier Stephen C |
| |
Affiliation: | Department of Chemistry and Biochemistry, Clippinger Laboratories, Ohio University, Athens, Ohio 45701, USA. |
| |
Abstract: | Synthetic or natural aza-sugars have shown promise as a therapeutic approach to a variety of disease states by acting as transition state mimics to sugar processing enzymes. Although the synthesis of functionalized bicyclo[3.2.1]octanes has been reported, the procedures are relatively long and low yielding. Herein, we report the facile synthesis of polyhydroxylated 2-azabicyclo[3.2.1]octane that can be selectively functionalized. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|