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Three-component synthesis of cyclic enaminones via ketene cyclization
Authors:Seki Hajime  Georg Gunda I
Affiliation:Department of Chemistry, Institute for Therapeutics Discovery and Development, College of Pharmacy, University of Minnesota, 717 Delaware Street SE, Minneapolis, Minnesota 55414, United States.
Abstract:Cyclic six-membered enaminones were synthesized from three components (bromodiazoacetone, primary amine, and alkyne) in high yields via aza-Michael addition, Wolff rearrangement, and nucleophilic ketene cyclization.
Keywords:
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