Preparation,characterization and in vitro antitumoral activity of a nanosize liposome complex encapsulated polyoxotungstate K6H2[CoW11TiO40]

The nanosize liposome complex-encapsulated polyoxotungstate K₆H₂[CoW₁₁TiO₄₀] has been prepared and structurally characterized by i.r., u.v.–vis and e.s.r. spectra. The particle size of the liposome complex-encapsulated K₆H₂[CoW₁₁TiO₄₀], is distributed in two uncontinuous limits in which 98.9% of particles distributed in the limit of 62.8–76.7 nm, average diameter, is 69.4 nm. The result shows that the polyoxotungstate retains the parent structure after being encapsulated by liposome, and that liposomal encapsulation increase the antitumoral activity of the polyoxometalate.