THE EFFECT OF pH ON THE FLUORESCENCE OF COMPLEXES OF HUMAN SERUM ALBUMIN AND BOVINE SERUM ALBUMIN WITH BILIRUBIN |
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| Authors: | J J Lee G D Gillispie |
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| Institution: | Chemistry Department, State University of New York at Albany, 1400 Washington Avenue, Albany, NY 12222, USA |
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| Abstract: | Abstract— Fluorescence studies as a function of pH clearly show that the environment and conformation of bilirubin bound to human serum albumin (HSA) are quite different than those for binding to bovine serum albumin (BSA). The visible fluorescence of the bilirubin-BSA complex is maximal at the extremes of pH; in contrast, the bilirubin-HSA complex fluorescence is at a maximum, near physiological pH. |
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