(-)-Hydroxylindestrenolide, a new sesquiterpenoid from a gorgonian coral Menella sp. (Plexauridae) |
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Authors: | Kao Shih-Yao Chang Yu-Chia Su Jui-Hsin Lu Mei-Chin Chen Yung-Husan Sheu Jyh-Horng Wen Zhi-Hong Wang Wei-Hsien Kuo Yueh-Hsiung Hwang Tsong-Long Sung Ping-Jyun |
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Affiliation: | Graduate Institute of Marine Biotechnology, National Dong Hwa University, Taiwan. |
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Abstract: | (-)-Hydroxylindestrenolide (1), an enantiomer of the known sesquiterpenoid, (+)-hydroxylindestrenolide (2), was isolated from a gorgonian coral identified as Menella sp. The structure, including the relative stereochemistry of 1 was established by spectroscopic methods and by comparison the spectral and physical data with those of 2. Sesquiterpenoid 1 exhibited marginal cytotoxicity toward HL-60 and K562 leukemia tumor cells, and displayed a weak inhibitory effect on superoxide anion generation at a concentration of 10 μg/ml by human neutrophils. |
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