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Microbial conversion of curcumin into colorless hydroderivatives by the endophytic fungus Diaporthe sp. associated with Curcuma longa |
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| Authors: | Maehara Shoji Ikeda Michiteru Haraguchi Hiroyuki Kitamura Chinami Nagoe Tetsuro Ohashi Kazuyoshi Shibuya Hirotaka |
| Affiliation: | Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Japan. |
| Abstract: | We investigated the microbial conversion of curcumin (1) using endophytic fungi associated with the rhizome of Curcuma longa (Zingiberaceae). We found that Diaporthe sp., an endophytic filamentous fungus, converts curcumin (1) into four colorless derivatives, namely (3R,5R)-tetrahydrocurcumin (2), a novel (3R,5S)-hexahydrocurcumin (3) named neohexahydrocurcumin, (3S,5S)-octahydrocurcumin (4) and meso-octahydrocurcumin (5). |
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