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Synthesis of modified triazole nucleosides possessing one or two base moieties via a click chemistry approach |
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| Authors: | Sakellarios TrakossasEvdoxia Coutouli-Argyropoulou Dimitra J Hadjipavlou-Litina |
| Institution: | a Laboratory of Organic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece b Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece |
| Abstract: | Copper-catalyzed 1,3-dipolar cycloaddition of propargyl and azidoethyl thymine and adenine derivatives afforded triazole nucleosides bearing one or two base moieties. A catalytic role of the adenine nucleus was observed and is explained through copper-adenine coordination in the intermediate copper acetylide-azide complex. The antioxidant activity of the obtained cycloadducts was tested. |
| Keywords: | Nucleosides Triazoles Click chemistry 1 3-Dipolar cycloaddition reaction Copper catalysis |
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