Palladium(0)‐Catalyzed Intermolecular Allylic Dearomatization of Indoles by a Formal [4+2] Cycloaddition Reaction |
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| Authors: | Run‐Duo Gao Qing‐Long Xu Bo Zhang Yiting Gu Prof. Li‐Xin Dai Prof. Dr. Shu‐Li You |
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| Affiliation: | 1. http://shuliyou.sioc.ac.cn/;2. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, P. R. China;3. +86)?21‐5492‐5087;4. Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, P. R. China |
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| Abstract: | Bridged indoline derivatives were synthesized by an intermolecular Pd‐catalyzed allylic dearomatization reaction of substituted indoles. The reaction between indoles and allyl carbonates bearing a nucleophilic alcohol side‐chain proceeds in a cascade fashion, providing bridged indolines in excellent enantioselectivity. |
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| Keywords: | asymmetric catalysis dearomatization indole indoline palladium |
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