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Diastereoselective Coupling of Chiral Acetonide Trisubstituted Radicals with Alkenes |
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| Authors: | Daniel J Tao Dr Mikko Muuronen Yuriy Slutskyy Alexander Le Prof Filipp Furche Prof Larry E Overman |
| Institution: | Department of Chemistry, University of California Irvine, Irvine, CA, USA |
| Abstract: | The stereochemical outcome of reactions of chiral nucleophilic trisubstituted acetonide radicals with electron‐deficient alkenes is dictated by a delicate balance between destabilizing non‐bonding interactions and stabilizing hydrogen‐bonding between substituents on the α and β carbons. |
| Keywords: | ab initio calculations alkenes radical reactions stereoselectivity |