A Pd‐Catalyzed Synthesis of Functionalized Piperidines |
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| Authors: | Benjamin D. W. Allen Dr. Matthew J. Connolly Prof. Joseph P. A. Harrity |
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| Affiliation: | Department of Chemistry, University of Sheffield, Sheffield, U.K. |
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| Abstract: | A readily available cyclic carbamate 1 functions as a general precursor to a range of functionalized piperidine products via a new Pd‐catalyzed annulation strategy. An asymmetric catalytic variant provides a rapid and efficient means to access these heterocycles with high to excellent levels of enantiocontrol. Finally, these richly functionalized compounds are amenable to further chemoselective elaboration. |
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| Keywords: | annulation enantioselectivity Pd catalysis piperidine |
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