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Rhodium(I)‐Catalyzed Benzannulation of Heteroaryl Propargylic Esters: Synthesis of Indoles and Related Heterocycles |
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| Authors: | Dr Xiaoxun Li Dr Haibo Xie Xiaoning Fu Ji‐tian Liu Hao‐yuan Wang Prof Dr Bao‐min Xi Prof Dr Peng Liu Prof Dr Xiufang Xu Prof Dr Weiping Tang |
| Institution: | 1. School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA;2. Department of Chemistry, Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Nankai University, Tianjin, P. R. China;3. Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Gaungzhou, Guangdong, P. R. China;4. Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, USA;5. Department of Chemistry, University of Wisconsin-Madison, Madison, WI, USA |
| Abstract: | A de novo synthesis of a benzene ring allows for the preparation of a diverse range of heterocycles including indoles, benzofurans, benzothiophenes, carbazoles, and dibenzofurans from simple heteroaryl propargylic esters using a unified carbonylative benzannulation strategy. Multiple substituents can be easily introduced to the C4–C7 positions of indoles and related heterocycles. |
| Keywords: | annulation carbonylation catalysis indoles rhodium |