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Stereoretentive Copper‐Catalyzed Directed Thioglycosylation of C(sp2)−H Bonds of Benzamides |
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| Authors: | Amélie Chabrier Dr Alexandre Bruneau Sara Benmahdjoub Dr Belkacem Benmerad Dr Sabrina Belaid Jean‐Daniel Brion Dr Mouâd Alami Dr Samir Messaoudi |
| Institution: | 1. BioCIS, Univ. Paris-Sud, CNRS, University Paris-Saclay, Chatenay-Malabry, France;2. Laboratoire de Physico-Chimie des Matériaux et Catalyse, Faculté des Sciences Exactes, Université de Bejaia, Bejaia, Algeria |
| Abstract: | An efficient thioglycosylation of C(sp2)?H bonds with thiosugars has been established for the first time. Using only Cu(OAc)2?H2O as a catalyst and Ag2CO3 as an additive in DMSO, the protocol proved to have broad scope, and a variety of complex thioglycosides have been prepared in good yields with exclusive β‐selectivity. |
| Keywords: | C− H bond activation copper homogeneous catalysis thioglycosides thioglycosylation reaction |