How Does Solvation Affect the Binding of Hydrophilic Amino Saccharides to Cucurbit[7]uril with Exceptional Anomeric Selectivity? |
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Authors: | Jianping Wang Yoonjung Jang Jayshree K Khedkar Jin Young Koo Yonghwi Kim Chang Jun Lee Young Min Rhee Kimoon Kim |
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Institution: | 1. Center for Self-assembly and Complexity, Institute for Basic Science (IBS), Pohang, Republic of Korea;2. Department of Chemistry, Pohang University of Science and Technology, Pohang, Republic of Korea;3. Division of Advanced Materials Science, Pohang University of Science and Technology, Pohang, Republic of Korea |
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Abstract: | Cucurbit7]uril (CB7]) is known to bind strongly to hydrophilic amino saccharide guests with exceptional α‐anomer selectivities under aqueous conditions. Single‐crystal X‐ray crystallography and computational methods were used to elucidate the reason behind this interesting phenomenon. The crystal structures of protonated galactosamine (GalN) and glucosamine (GluN) complexes confirm the inclusion of α anomers inside CB7] and disclose the details of the host–guest binding. Whereas computed gas‐phase structures agree with these crystal structures, gas‐phase binding free energies show preferences for the β‐anomer complexes over their α counterparts, in striking contrast to the experimental results under aqueous conditions. However, when the solvation effect is considered, the binding structures drastically change and the preference for the α anomers is recovered. The α anomers also tend to bind more tightly and leave less space in the CB7] cavity toward inclusion of only one water molecule, whereas loosely bound β anomers leave more space toward accommodating two water molecules, with markedly different hydrogen‐bonding natures. Surprisingly, entropy seems to contribute significantly to both anomeric discrimination and binding. This suggests that of all the driving factors for the strong complexation of the hydrophilic amino saccharide guests, water mediation plays a crucial role in the anomer discrimination. |
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Keywords: | anomeric selectivity host– guest systems molecular dynamics solvent effects supramolecular chemistry |
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