pH‐Responsive Relaxometric Behaviour of Coordination Polymer Nanoparticles Made of a Stable Macrocyclic Gadolinium Chelate |
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| Authors: | Javier Aríñez‐Soriano Jorge Albalad Arnau Carné‐Sánchez Célia S Bonnet Prof Félix Busqué Prof Julia Lorenzo Jordi Juanhuix Maxwell W Terban Inhar Imaz Prof Éva Tóth Prof Daniel Maspoch |
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| Institution: | 1. Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and The Barcelona Institute of Science and Technology, Campus UAB, Bellaterra, Barcelona, Spain;2. Centre de Biophysique Moléculaire, CNRS, Université d'Orléans, Orléans, France;3. Departament de Química, Universitat Autònoma de Barcelona, Campus UAB, Bellaterra, Barcelona, Spain;4. Departament de Bioquímica i Biologia Molecular, Institut de Biotecnologia i Biomedicina (IBB), Campus UAB, Bellaterra, Spain;5. ALBA Synchrotron, Cerdanyola del Vallès, Barcelona, Spain;6. Department of Applied Physics and Applied Mathematics, Columbia University, New York, USA;7. ICREA, Pg. Lluís Companys 23, Barcelona, Spain |
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| Abstract: | Lanthanide‐containing nanoscale particles have been widely explored for various biomedical purposes, however, they are often prone to metal leaching. Here we have created a new coordination polymer (CP) by applying, for the first time, a stable GdIII chelate as building block in order to prevent any fortuitous release of free lanthanide(III) ion. The use of the Gd‐DOTA‐4AmP complex as a design element in the CP allows not only for enhanced relaxometric properties (maximum r1=16.4 mm ?1 s?1 at 10 MHz), but also for a pH responsiveness (Δr1=108 % between pH 4 and 6.5), beyond the values obtained for the low molecular weight Gd‐DOTA‐4AmP itself. The CP can be miniaturised to the nanoscale to form colloids that are stable in physiological saline solution and in cell culture media and does not show cytotoxicity. |
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| Keywords: | chelates contrast agents coordination polymers gadolinium relaxometry |
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