Pd‐Catalyzed C−H Alkylation of Arenes Using PyrDipSi,a Transformable and Removable Silicon‐Tethered Directing Group |
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| Authors: | Dhruba Sarkar Prof. Dr. Vladimir Gevorgyan |
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| Affiliation: | 1. http://www.chem.uic.edu/vggroup;2. Department of Chemistry, University of Illinois at Chicago, Chicago, IL, USA;3. (+1)?312‐355‐0836 0000-0002-7836-7596 Department of Chemistry, University of Illinois at Chicago, Chicago, IL, USA |
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| Abstract: | An efficient Pd‐catalyzed ortho‐C?H alkylation reaction of arenes using a transformable and removable Si‐tethered pyridyldiisopropylsilyl (PyrDipSi) directing group has been developed. In addition, the PyrDipSi directing group allows for an efficient sequential double‐fold C?H alkylation/oxygenation of arenes to produce meta‐alkylated phenols. This directing group can easily be removed or converted into valuable functionalities, such as aryl, iodo, boronic ester, or phenol. |
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| Keywords: | catalysis C− H alkylation directing group palladium silicon |
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