| Fluorescence enhancing by alkaline degradation of tetracycline antibiotics and its application |
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| 作者姓名： | 赵一兵 慈云祥 常文保 |
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| 作者单位： | Department of Chemistry，The Research Laboratory of SEDC of Analytical Science for Material and Life Chemistry，Xiamen University，Xiamen 361005，China，Department of Chemistry，Peking University，Beijing 100871，China，Department of Chemistry，Peking University，Beijing 100871，China |
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| 基金项目： | Project supported by the National Natural Science Foundation of China，the Provincial Natural Science Foundation of Fujian |
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| 摘 要： | Tetracycline antibiotics could be degraded after being beated in boiling-water bath in alkaline solution (in KOH medium).The fluorescence excitation and emission wavelengths of the degradation products changed and the fluorescence intensity increased by 5-190 folds as compared with that of antibiotics themselves It was considered that there occurred a nucleophilic ring rupture reaction to form the degradation products with lactome structure The mteraction of the lone pair electrons of oxygen on the degradation products with the conjugated π electrons induced the in crease of the delocalization for the conjugated electron system in the molecule and thus enhanced the fluorescence intensity.
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| 收稿时间： | 15 January 1997 |
Fluorescence enhancing by alkaline degradation of tetracycline antibiotics and its application |
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| Yibing Zhao,Yunxiang Ci,Wenbao Chang.Fluorescence enhancing by alkaline degradation of tetracycline antibiotics and its application[J].Science in China(Chemistry),1997,40(4):434-441. |
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| Authors: | Yibing Zhao Yunxiang Ci Wenbao Chang |
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| Institution: | (1) Department of Chemistry, The Research Laboratory of SEDC of Analytical Science for Material and Life Chemistry, Xiamen University, 361005 Xiamen, China;(2) Department of Chemistry, Peking University, 100871 Beijing, China |
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| Abstract: | Tetracycline antibiotics could be degraded after being heated in boiling-water bath in alkaline solution (in KOH medium).
The fluorescence excitation and emission wavelengths of the degradation products changed and the fluorescence intensity increased
by 5–190 folds as compared with that of antibiotics themselves. It was considered that there occurred a nucleophilic ring
rupture reaction to form the degradation products with lactonic structure. The interaction of the lone pair electrons of oxygen
on the degradation products with the conjugated π electrons induced the increase of the delocalization for the conjugated
electron system in the molecule and thus enhanced the fluorescence intensity.
Project supported by the National Natural Science Foundation of China and the Provincial Natural Science Foundation of Fujian. |
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| Keywords: | tetracycline antibiotics alkaline degradation fluorimetry |
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