| DNA双链断裂的组成与自由基清除效能的关系 |
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| 引用本文： | 邵春林,齐藤真弘,余增亮.DNA双链断裂的组成与自由基清除效能的关系[J].物理化学学报,2000,16(2):184-187. |
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| 作者姓名： | 邵春林 齐藤真弘 余增亮 |
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| 作者单位： | Laboratory of lon Beam Bioengineering,Institute of Plasma Physics,the Chinese Academy of Science,Hefei 230031,Research Reaator Institute,Kyoto University,Osaka 5900494,Japan |
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| 基金项目： | 国家自然科学基金资助项目(19605005) |
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| 摘 要： | ＤＮＡ双链断裂（ＤＳＢ）是重要的辐射生物学效应之一 ,它是导致细胞死亡和变异的主要因素［１，２］．大量研究表明 ,ＤＳＢ由αＤＳＢ和 βＤＳＢ两部分组成 ,分别为电离辐射能量沉积的单击作用 (包括ＬＭＤＳ机制和单自由基传递机制 )和双击作用所致［３ -５］．但对不同的生物体系 ,由于靶体积大小等不一 ,α、β有不同的值．从根本上讲 ,α、β与电离辐射的径迹如粒子的种类、ＬＥＴ等有关 ,α在中等ＬＥＴ时最大 ,而 β则在低ＬＥＴ辐射时占优势［６］．研究α、β 与生物体系之间的关系 ,将有助于加深人们对电离辐射物理化学效应的…
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| 关 键 词： | 电离辐射 pBR322 DNA双链断裂(DSB)组成 甘露醇 |
| 收稿时间： | 1999-03-24 |
| 修稿时间： | 1999年3月24日 |
Relationship between the Constitutes of DNA Double Strand Breaks and Scavenging Capacity |
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| Shao Chunlin,SAITO Masahiro,Yu Zengliang.Relationship between the Constitutes of DNA Double Strand Breaks and Scavenging Capacity[J].Acta Physico-Chimica Sinica,2000,16(2):184-187. |
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| Authors: | Shao Chunlin SAITO Masahiro Yu Zengliang |
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| Institution: | Laboratory of lon Beam Bioengineering,Institute of Plasma Physics,the Chinese Academy of Science,Hefei 230031|Research Reaator Institute,Kyoto University,Osaka 5900494,Japan |
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| Abstract: | Measured by gel electrophoresis scanning,it was shown that the double-strand breaks (DSBs) of pBR322 irradiated by γ-rays were constituted by two parts,α DSB and β DSB,and the relationship between α ,β and scavenging capacity σ was obtained.Results showed that β /α non-linearly decreased with increasing σ .Moreover,the yield of the OH free radicals reacting with DNA was analyzed. |
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| Keywords: | Irradiation pBR322 Constitutes of DSB Mannitol |
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