Peptide-small molecule hybrids via orthogonal deprotection-chemoselective conjugation to cysteine-anchored scaffolds. A model study |
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| Authors: | Smith Amos B Savinov Sergey N Manjappara Uma V Chaiken Irwin M |
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| Institution: | Department of Chemistry and Department of Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. smithab@sas.upenn.edu |
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| Abstract: | The feasibility of an orthogonal deprotection-conjugation protocol, holding the promise of libraries of functionally diverse chemical probes attached to cysteine-anchored peptide scaffolds, has been explored with a model system. The necessary tools for assembly of the hybrid libraries have been prepared and the tandem procedure optimized. S-alkylation and S-sulfenylation are featured as the chemoselective ligation reactions. reaction: see text] |
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