Phosphine‐Catalyzed Asymmetric Umpolung Addition of Trifluoromethyl Ketimines to Morita–Baylis–Hillman Carbonates |
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| Authors: | Peng Chen Zhenting Yue Junyou Zhang Xi Lv Lei Wang Prof Dr Junliang Zhang |
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| Institution: | 1. http://faculty.ecnu.edu.cn/s/1811/main.jspy;2. Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, P.R. China |
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| Abstract: | A novel phosphine‐catalyzed, highly enantioselective umpolung addition of trifluoromethyl ketimines to Morita–Baylis–Hillman carbonates was developed and it provides facile access to optically active trifluoromethyl amines with a chiral tertiary stereocenter under mild reaction conditions. The salient features of this reaction include general substrate scope, mild reaction conditions, good yields, high enantioselectivity, ease of scale‐up to gram scale, and further transformations of the products. |
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| Keywords: | asymmetric catalysis enantioselectivity fluorine organocatalysis umpolung |
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