Sterically Congested 2,6‐Disubstituted Anilines from Direct C−N Bond Formation at an Iodine(III) Center |
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| Authors: | Nicola Lucchetti Dr Michelangelo Scalone Dr Serena Fantasia Prof Dr Kilian Muñiz |
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| Institution: | 1. Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Tarragona, Spain;2. F. Hoffmann-La Roche Ltd, Process Research & Development, Basel, Switzerland;3. ICREA, Barcelona, Spain |
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| Abstract: | 2,6‐Disubstituted anilines are readily prepared from the direct reaction between amides and diaryliodonium salts. As demonstrated for 24 different examples, the reaction is of unusually broad scope with respect to the sterically congested arene and the nitrogen source, occurs without the requirement for any additional promoter, and proceeds through a direct reductive elimination at the iodine(III) center. The efficiency of the coupling procedure is further demonstrated within the short synthesis of a chemerin binding inhibitor. |
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| Keywords: | amination anilines arylation hypervalent iodine phthalimide |
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