Enantioselective Generation of Adjacent Stereocenters in a Copper‐Catalyzed Three‐Component Coupling of Imines,Allenes, and Diboranes |
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Authors: | Kay Yeung Rebecca E Ruscoe Dr James Rae Dr Alexander P Pulis Prof?Dr David J Procter |
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Institution: | School of Chemistry, University of Manchester, Manchester, UK |
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Abstract: | A highly enantio‐ and diastereoselective copper‐catalyzed three‐component coupling affords the first general synthesis of homoallylic amines bearing adjacent stereocenters from achiral starting materials. The method utilizes a commercially available NHC ligand and copper source, operates at ambient temperature, couples readily available simple imines, allenes, and diboranes, and yields high‐value homoallylic amines that exhibit versatile amino, alkenyl, and boryl units. |
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Keywords: | amines asymmetric catalysis boron copper multicomponent reactions |
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