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Trapping σ‐Alkyl–Palladium(II) Intermediates with Arynes Encompassing Intramolecular C−H Activation: Spirobiaryls through Pd‐Catalyzed Cascade Reactions
Authors:Marta Pérez‐Gómez  Dr José‐Antonio García‐López
Institution:Grupo de Química Organometálica. Dpto. Química Inorgánica, Universidad de Murcia, Murcia, Spain
Abstract:A palladium‐catalyzed cascade reaction based on the trapping of transient alkyl–PdII intermediates with arynes encompassing a C?H activation step has been developed. This synthetic pathway gives rise to hetero‐spirocyclic scaffolds containing a biaryl motif, and opens up new synthetic strategies in the design of cascade reactions since it gathers several aspects of Pd chemistry, i.e., intra‐ and intermolecular carbopalladation of unsaturated species, C?H activation and C?C coupling processes.
Keywords:aryne  carbopalladation  cascade reactions  C−  H activation  spirocycles
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