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Block Copolymer Capsules with Structure‐Dependent Release Behavior
Authors:Dr. Jiangping Xu  Dr. Jun Li  Yi Yang  Dr. Ke Wang  Nan Xu  Dr. Jingyi Li  Dr. Ruijing Liang  Prof. Lei Shen  Prof. Xiaolin Xie  Prof. Juan Tao  Prof. Jintao Zhu
Affiliation:1. Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), Wuhan, China;2. Department of Dermatology, Union Hospital, Tongji Medical College, HUST, Wuhan, China
Abstract:Although high‐boiling non‐solvent induced macrophase separation in emulsion droplets has been widely applied for the fabrication of polymeric capsules, precise control of their structures remains a great challenge. Herein, block copolymer capsules with tunable shell structures were fabricated by employing a non‐solvent as a liquid template in emulsion droplets. The properties of the non‐solvents dictate the phase separation sequence in the droplets and the capsule formation mechanism. Two different pathways for capsule formation were observed, and could be applied to predict the shell structure. The structured capsules could be transformed into mesoporous capsules, which demonstrated an intriguing structure‐dependent release behavior. Capsules with spherical shell structures displayed the best permeability, while those with lamellar shell structures showed the slowest release, but with a stepwise profile. After loading with an anticancer drug, different capsules induced different apoptosis ratios in cancer cell studies.
Keywords:apoptosis  block copolymers  capsules  controlled release  phase separation
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