Comparison of monomode and multimode microwave equipment in Suzuki-Miyaura reactions—en route to high throughput parallel synthesis under microwave conditions |
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Authors: | Uwe Schö n,Josef Messinger,Andreas Kirschning |
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Affiliation: | a Solvay Pharmaceutical Research Laboratories, Hans-Böckler-Allee 20, D-30173 Hannover, Germany b Institut für Organische Chemie and Zentrum für Biomolekulare Wirkstoffe (BMWZ), Leibniz Universität Hannover, Schneiderberg 1B, D-30167 Hannover, Germany |
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Abstract: | The microwave heated Suzuki-Miyaura cross-coupling reaction of boronic acids, boronic esters and organotrifluoroborates served as a model reaction in a singlemode equipment. The reaction conditions were optimized with respect to temperature and reaction time and were transferred to multimode equipment which is well suited for multiparallel synthesis in a larger scale. The source of the Pd species chosen included immobilized Pd complexes and Pd particles. In fact the increased time to reach the required reaction time in multimode chambers suitable for 48 parallel reactions has to be taken into account. The nature of the boronic acid has no impact on the efficiency of the catalytic process. However, heterogenized Pd species perform less well in multimode chambers with larger vial volumes, which we ascribe to diffusion phenomena. |
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Keywords: | Suzuki-Miyaura reaction Microwave Monomode Multimode Palladium precatalysts |
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